To commercialize a biomedical product as a medical device, reproducibility of production and time-stability are important parameters. Studies of reproducibility are lacking in the literature. Additionally, chemical pre-treatments of wood fibres to produce highly fibrillated cellulose nanofibrils (CNF) seem to be demanding in terms of production efficiency, being a bottleneck for industrial upscaling. In this study, we evaluated the effect of pH on the dewatering time and washing steps of 2,2,6,6-Tetramethylpiperidinyloxy (TEMPO)-mediated oxidized wood fibres when applying 3.8mmol NaClO/g cellulose. The results indicate that the method does not affect the carboxylation of the nanocelluloses, and levels of approximately 1390μmol/g were obtained with good reproducibility. The washing time of a Low-pH sample was reduced to 1/5 of the time required for washing a Control sample. Additionally, the stability of the CNF samples was assessed over 10months and changes were quantified, the most pronounced were the increase of potential residual fibre aggregates, reduction of viscosity and increase of carboxylic acid content. The cytotoxicity and skin irritation potential were not affected by the detected differences between the Control and Low-pH samples. Importantly, the antibacterial effect of the carboxylated CNFs against S. aureus and P. aeruginosa was confirmed.
Fra nanofiber i sårsalve til verdens høyeste trehus.
Interview in Svensk Papperstidning
The journal “Svensk Papperstidning” has recently published an interview with RISE PFI regarding RISE PFIs research within nanocelluloses (Svensk Papperstidning no. 2/22). Read more...
2021 TAPPI NanoDivision Mid-Career Award
Development of sustainable biobased materials to replace fossil-based plastics. Read more...
The BioComp project has been highlighted in Compounding World. We continue our efforts on assisting the industry with the implementation and realization of commercial products. Read more...
Interview in Compouding world - 2020
"Environmental concerns with plastic littering are motivating the development of sustainable biocomposites, where biobased plastics reinforced with lignocellulosic fibres are clear options. " Read more...
“Our innovation project can be divided into two specific biomedical developments. First, we focused on the development of an innovative prosthesis that improves the quality of life of vulnerable patients with cancer in the pelvic cavity. Secondly, we have produced oxygenated nanocelluloses for wound dressings.” Read more...
Elicitors from food residues - LinkedIn
“Innovative solutions to waste streams in the wine and fruit juice industries have been developed in this project, extracting medium to high-added value mixtures that can be used as plant immune-system elicitors in green-houses and farms, with the potential to reduce the need for agrochemicals”, Read more...
Turning agricultural biowaste into high-value 3D-printing materials
Bagasse is an agro-industrial residue with major potential for several high-value products. Read more...
Surface-modified nanocellulose hydrogels for wound dressing. NanoWerk
Cellulose is a biopolymer consisting of long chains of glucose with unique structural properties whose supply is practically inexhaustible. It is found in the cell walls of plants where it serves to provide a supporting framework – a sort of skeleton. Nanocellulose from wood – i.e. wood fibers broken down to the nanoscale – is a promising nanomaterial with potential applications as a substrate for printing electronics, filtration, or biomedicine. Read more...