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Examples of interdisciplinary research


Characterization and Antibacterial Properties of Autoclaved Carboxylated Wood Nanocellulose

Cellulose nanofibrils (CNFs) were obtained by applying a chemical pretreatment consisting of autoclaving the pulp fibers in sodium hydroxide, combined with 2,2,6,6-tetramethylpiperidinyl-1-oxyl-mediated oxidation. Three levels of sodium hypochlorite were applied (2.5, 3.8, and 6.0 mmol/g) to obtain CNF qualities (CNF_2.5, CNF_3.8, and CNF_6.0) with varying content of carboxyl groups, that is, 1036, 1285, and 1593 μmol/g cellulose. The cytotoxicity and skin irritation potential (indirect tests) of the CNFs were determined according to standardized in vitro testing for medical devices. We here demonstrate that autoclaving (121 °C, 20 min), which was used to sterilize the gels, caused a modification of the CNF characteristics. This was confirmed by a reduction in the viscosity of the gels, a morphological change of the nanofibrils, by an increase of the ultraviolet–visible absorbance maxima at 250 nm, reduction of the absolute zeta potential, and by an increase in aldehyde content and reducing sugars after autoclaving. Fourier-transform infrared spectroscopy and wide-angle X-ray scattering complemented an extensive characterization of the CNF gels, before and after autoclaving. The antibacterial properties of autoclaved carboxylated CNFs were demonstrated in vitro (bacterial survival and swimming assays) on Pseudomonas aeruginosa and Staphylococcus aureus. Importantly, a mouse in vivo surgical-site infection model on S. aureus revealed that CNF_3.8 showed pronounced antibacterial effect and performed as good as the antiseptic Prontosan wound gel

2021 TAPPI NanoDivision Mid-Career Award

Nanotechnology Division Mid-Career Award for research contributions related to the nanotechnology of renewable materials and contributions to the technical community.  Read more...

Compouding world - May 2021

The BioComp project has been highlighted in Compounding World. We continue our efforts on assisting the industry with the implementation and realization of commercial products. Read more...
Compounding World May 2021 :: 32 : https://cutt.ly/JbxLI1q

Interview in Compouding world - 2020

"Environmental concerns with plastic littering are motivating the development of sustainable biocomposites, where biobased plastics reinforced with lignocellulosic fibres are clear options. "  Read more...

Testimonial in MANUNET

“Our innovation project can be divided into two specific biomedical developments. First, we focused on the development of an innovative prosthesis that improves the quality of life of vulnerable patients with cancer in the pelvic cavity. Secondly, we have produced oxygenated nanocelluloses for wound dressings.” Read more...