Oxygenated Nanocellulose—A Material Platform for Antibacterial Wound Dressing Devices
Both carboxylated cellulose nanofibrils (CNF) and dissolved oxygen (DO) have been reported to possess antibacterial properties. However, the combination for use as wound dressings against biofilm infections in chronic wounds is less known. The present study reports the development of oxygenated CNF dispersions that exhibit strong antibacterial effect. Carboxylated CNF dispersions with different oxidation levels were oxygenated by the OXY BIO System and tested for antibacterial activity againstPseudomonas aeruginosaandStaphylococcus aureus. The results reveal that the higher oxidation level of the CNFs, the better antibacterial effect. Scanning electron microscopy of bacterial biofilms revealed that a potential mechanism of action of the CNFs is the formation of a network surrounding and entrapping the bacteria. This effect is further potentiated by the oxygenation process. A CNF sample (concentration 0.6 wt %) that was oxygenated to a DO level of 46.4 mg/L demonstrated a strong antibacterial effect againstS. aureusin vivousing a mouse model of surgical site infection. The oxygenated CNF dispersion reduced the bacterial survival by 71%, after 24 h treatment. The potent antibacterial effect indicates that oxygenated nanocellulose is a promising material for antibacterial wound dressings.
Alle gode ting er tre
Fra nanofiber i sårsalve til verdens høyeste trehus.
Interview in Svensk Papperstidning
The journal “Svensk Papperstidning” has recently published an interview with RISE PFI regarding RISE PFIs research within nanocelluloses (Svensk Papperstidning no. 2/22). Read more...
2021 TAPPI NanoDivision Mid-Career Award
Nanotechnology Division Mid-Career Award for research contributions related to the nanotechnology of renewable materials and contributions to the technical community. Read more...
Compouding world - May 2022
Development of sustainable biobased materials to replace fossil-based plastics. Read more...
Compouding world - May 2021
The BioComp project has been highlighted in Compounding World. We continue our efforts on assisting the industry with the implementation and realization of commercial products. Read more...
Interview in Compouding world - 2020
"Environmental concerns with plastic littering are motivating the development of sustainable biocomposites, where biobased plastics reinforced with lignocellulosic fibres are clear options. " Read more...
Testimonial in MANUNET
“Our innovation project can be divided into two specific biomedical developments. First, we focused on the development of an innovative prosthesis that improves the quality of life of vulnerable patients with cancer in the pelvic cavity. Secondly, we have produced oxygenated nanocelluloses for wound dressings.” Read more...
